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KMID : 1134819970260030528
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Journal of the Korean Society of Food Science and Nutrition
1997 Volume.26 No. 3 p.528 ~ p.533
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Inhibitory Effects of Synurus deltoides Extracts on the Mutagenesis Induced by Various Mutagens
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Ham Seung-Shi
Han Hong-Sik
Choi Kun-Pyo
Oh Deog-Hwan
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Abstract
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This study was undertaken to determine the antimutagenic effects of Synurus deltoides extracts on the mutagenesis induced by 3-amino-1,4-dimethyl-5-H-pyrido[4,3-b]indol(Trp-P-1), 2-aminofluorene(2-AF) and 4-nitroquinolin-1-oxide(4NQO) using Ames test. Raw juice, heated juice, and ethanol extract from Synurus deltoides itself did not induce mutagenesis. The raw juice, heated juice and ethanol extract of 5μl/plate showed approximately 90%, 37% and 28% inhibitory effect on the mutagenesis induced by Trp-P-1 against TA98 strain, while 80%, 60% and 58% inhibition was observed on the mutagenesis induced by 2-AF at the concentration of 200μl/plate, respectively. TA100 strain was more sensitive than TA98 strain by raw juice, heated juice and ethanol extract on the mutagenesis induced by Trp-p-1 and 2-AF. Meanwhile, the raw juice, heated juice, and ethanol extract showed very limited inhibitory effects on the mutagenesis induced by 4-NQO against TA98 and TA100 strain. These results indicate that raw juice had the strongest inhibitory effect on the Trp-P-1 or 2-AF induced mutagenesis, but all of the extracts had a little antimutagenic effects on the 4-NQO induced mutagenesis.
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KEYWORD
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antimutagenicity, Synurus deltoides, Ames test
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